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Bile Formation and Secretion - PMC - PubMed Central (PMC) Sperber was the first to articulate the “osmotic theory of bile formation” in a classic review entitled “Secretion of organic anions in the formation of urine and bile,” published in Pharmacological Reviews in 1959 . Sperber was a Swedish physiologist who worked at the Royal College of Agriculture in Uppsala. His report was heavily influenced by prior work of many different ... › pmc › articlesBile Formation and Secretion - PMC - PubMed Central (PMC) The hepatocyte is a highly polarized cell, whose apical excretory domain represents about 10% to 15% of the cell surface area (Fig. 1A). The remaining major portions of the cell membrane consist of the basal membrane that faces the blood sinusoids and contains many microvilli, and the smooth lateral membrane that lines the intercellular space ...

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